Fertility Study of the effect on fertility have not been performed. Pregnancy As with other muscle relaxants, Trakrium should be used during pregnancy only when the potential benefit to the mother outweighs any possible risk to the fetus. Trakrium can be used for the purpose of muscle relaxation during caesarean section, so as in the appointment of the recommended doses Trakrium crosses the placental barrier fluoxymesterone powder valley in clinically insignificant amounts. Lactation It is unknown whether Trakrium breast milk in humans is released.
Interaction with other medicinal products and other interactions
induced Trakriumom neuromuscular blockade may be aggravated by the use of funds to inhalation anesthesia such as halothane, isoflurane, enflurane.
As with other non-depolarizing muscle relaxants may increase the intensity and / or duration of neuromuscular blockade as a result of interaction with the following preparations:
- antibiotics, including the aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin and clindamycin;
- antiarrhythmic agents: propranolol, calcium channel blockers, lidocaine, procainamide, and quinidine;
- diuretics furosemide and possibly mannitol, thiazide diuretics and acetazolamide;
- magnesium sulfate fluoxymesterone powder valley;
- lithium salts;
- ganglioplegic: trimetafan, hexamethonium.
In rare cases, certain drugs cause worsening of myasthenia gravis, myasthenia contribute to the development of the latent form, and myasthenic syndrome, in which it is possible to increase the sensitivity . Such drugs include various antibiotics, beta-blockers (propranolol, oxprenolol), antiarrhythmics (procainamide, quinidine) and antirheumatic drugs , trimetafan, chlorpromazine, steroids, phenytoin and lithium.
The development of neuromuscular blockade, caused by non-depolarizing muscle relaxants is likely to slow down, and its duration is reduced in patients receiving anticonvulsant therapy for a long time.
The combined use of non-depolarizing blockers neuromuscular conduction and fluoxymesterone powder valley can cause excessive blockade than expected from the introduction in equipotential total dose. Any effect due to synergy, may vary for different combinations of drugs. Depolarizing muscle relaxant suxamethonium chloride should not be used to prolong the neuromuscular blockade induced by non-depolarizing muscle relaxants because it can cause prolonged and complicated blockade, which is difficult to stop anticholinesterase agents.
Treatment with anticholinesterase drugs often used to treat Alzheimer’s disease, for example, donepezil, may shorten the duration of neuromuscular blockade and weaken the blocking effect.