Children aged 2 years and older Trakrium administered in the same dose as adults, based on body weight.
The starting dose Trakriuma applied in children aged 1 month to 2 years under halothane anesthesia, 0.3 – 0 4 mg / kg. Children may need more frequent use of maintenance doses fluoxymesterone molar mass of co2 than adults.
Elderly patients can be used in standard doses in elderly patients. However, the recommended starting dose, which is less than the lower value of the range of doses and inject the drug slowly. Use in patients with impaired renal function and / or liver. Trakrium can be used in standard doses for any degree of dysfunction of the liver or kidney problems, including the lack of a final stage. Use in patients with cardiovascular disease patients with cardiovascular disease with severe clinical symptoms initial dose should be administered within 60 seconds.
Use in patients after the introduction if necessary in the initial bolus dose of 0.3-0.6 mg / kg of the drug can be used to maintain neuromuscular blockade through a continuous infusion at a rate of 11-13 mg / kg / min (0,65-0,78 mg / kg / h). However, there are wide interindividual differences in dosing mode. The dosage regimen may vary over time. Some patients may require a low infusion rate – 4.5 mcg / kg / min (0.27 mg / kg / h) and high -29.5 pg / kg / min (1.77 mg / kg / h). The rate of spontaneous recovery from neuromuscular block at the end of infusion in patients Trakriuma BIT does not depend on the duration of administration.Spontaneous recovery of neuromuscular conduction (ratio height of the first quarter to twitch in the test train-of-four T 4 / T 1 > 0.75) normally takes approximately 60 minutes. In clinical studies, this period ranged from 32 to 108 min after infusion Trakriuma and its speed does not depend on the duration of drug administration.
Monitoring As with other neuromuscular blocking agents, throughout the period of application recommended to monitor neuromuscular function to determine the dosage regimen for each individual case.
Adverse events reported below fluoxymesterone molar mass of co2 are listed according to the anatomical and physiological classification and frequency of occurrence. The frequency is defined as follows: very common ( > 1/10), common ( >1/100 and <1/10), uncommon ( > 1/1000 and <1/100), rare ( > 1/10000, and <1 / 1000), very rare (<1/10000, including isolated cases), not known (can not be estimated from the data available in stock).Frequency categories very often, often, and rarely were formed on the basis of clinical trials of the drug. Frequency categories are rarely, very rarely have been formed on the basis of spontaneously reported.
Clinical studies From the cardiovascular system frequently : transient decrease fluoxymesterone molar mass of co2 in blood pressure, flushing of the skin. The respiratory system, organs, thoracic and mediastinal disorders Uncommon :. Bronchoconstriction These adverse events associated with the release of histamine.