Data on the use of the drug halotestin reviewsin patients infection receiving antiretroviral therapy are limited. The results of the study of the interaction in the combined use of bosentan and lopinavir + ritonavir in healthy volunteers have shown that bosentan concentration increases, reaching a maximum value for 4 days. Requires control tolerance therapy in patients receiving ritonavir in combination with protease inhibitors, increased activity, especially at the beginning of the treatment, since it is possible decrease in blood pressure, as well as changes in the activity of liver transaminases.With long-term use and antiretroviral drugs may increase the risk of adverse effects on liver function and blood count indices. In view of possible interactions associated with bosentan induction of cytochrome isoenzymes , antiretroviral activity may decrease, these patients need to carefully monitor the effectiveness of treatment.
resulting in severe chronic obstructive pulmonary disease
Efficacy and safety of bosentan studied in search of 12-week study involving 11 patients with secondary resulting in severe . The study results show an increase in minute ventilation rate and halotestin reviews reduce oxygen saturation; of the side effects most commonly noted shortness of breath, which decreases the severity of the abolition of bosentan.
The simultaneous use of other drugs
Glibenclamide: not recommended the simultaneous use and glibenclamide in connection with the risk of increased activity of “liver” transaminases. For the treatment of diabetes mellitus in patients who , should be used other hypoglycemic agents for ingestion or injection of insulin. Fluconazole: the simultaneous use of the drug fluconazole and halotestin reviewsis not recommended. Combination therapy has not been studied, but while the application may bosentan significant increase in plasma concentration. Rifampicin: simultaneous administration and rifampicin is not recommended. Applications drug combination and inhibitors isozyme to be avoided.