Post-marketing data Immune system Very rarely:. Anaphylactic and anaphylactoid reactions is very rare reports of severe anaphylactic or anaphylactoid reactions with concomitant use of medication with anesthetics. The nervous system is not known: convulsions. There were reported cases of seizures in patients on intensive care units, poluchayushih and other drugs, in addition to the drug halo testosterone Usually these patients were prerequisites for the occurrence of seizures, such as head trauma, cerebral edema, viral encephalitis, hypoxic encephalopathy, uremia. The relationship between the occurrence of seizures and laudanozinom not installed. As a result, clinical studies the correlation between plasma concentrations laudanozina and the occurrence of seizures is not available.
With the skin side and the subcutaneous fat Rarely :. Rash From the musculoskeletal system and connective tissue disorders Not known :. Myopathy, muscle weakness has been reported on several cases of myopathy and / or muscle weakness with prolonged use of muscle relaxants in severely ill patients in the intensive care unit. Most of them are at the same time receiving glucocorticoids. This adverse reaction halo testosterone is regarded as uncharacteristic for drug Trakrium ® , the connection with the use of the drug has not been established.
Overdose Signs Prolonged muscle paralysis and its consequences are the main signs of overdose. Treatment of maintaining airway patency is the most important concurrently with the ventilator positive pressure to restore adequate spontaneous respiration. It is necessary to use of sedatives, because the consciousness of patients are not disturbed. As soon as there are signs of spontaneous recovery it can be accelerated by using anticholinesterase drugs in combination with atropine or glycopyrrolate.
Specific guidance As with other muscle relaxants, causes paralysis of skeletal muscles, including the respiratory muscles, but does not affect consciousness. Should be administered only during general anesthesia under close supervision of an anesthesiologist in the presence of equipment for endotracheal intubation and mechanical ventilation.
When used in the recommended dose range does not cause significant blockade of the vagus nerve and the nerve ganglia. Consequently, the recommended dose range has no clinically significant effect on the heart rate and does not prevent the bradycardia caused by anesthetics or vagal stimulation during surgery. Patients with a tendency to sharp decrease in blood pressure, for example, hypovolemia, halo testosterone recommended to be administered for more than 60 seconds. Inactivated in an alkaline medium, and it should not be mixed in the same syringe with thiopentone or any alkaline solution. If the introduction is made into a vein small caliber after injection should be flushed with saline.
With the introduction of other anesthetics through the same injection needle or cannula is important that each drug was washed off the appropriate amount of saline solution. The solution hypotonic and must not be administered simultaneously through the same system with blood transfusions.Clinical studies in patients susceptible to malignant hyperthermia indicate not cause this syndrome. patients with burns may develop resistance to non-depolarizing muscle relaxants. In such cases may require increasing doses, the amount of which depends on the time elapsed after the burn, and the surface area of the burn. Patients BIT . ICU Patients receiving , convulsions were observed, however, a causal relationship with their development laudanozinom (a metabolite of atracurium besylate) is not installed (see. Adverse reactions ).